May 22, 2016 different routes of administration, their advantages and disadvantages, suitable dosage forms to be delivered. A drug given parenterally is one given by a route other than the mouth topical dosage forms are considered separately. Intravenous administration merits bypass first pass metabolism100% quick onset of action in uncooperative and unconscious patients those with nausea and vomiting hypertonic solutions and irritants large volumes amount of drug can be controlled accurately demerits antiseptic conditions depend on others painful and riskycant be recalled. The three main parenteral routes of drug administration are iv, im, and sc, and in all cases administration is usually via a hollow needle. Routes of drug administration definition a route of. To optimize therapy, it is desirable to search for nonparenteral routes of administration and to deliver the drug in a controlledrelease fashion. Routes of administration and dosage forms pharmacology. Jun 10, 2015 most of the drugs can be administered by variety of routes. Routes of drug administration 1st edition elsevier. Alternative routes of drug administration transdermal. Path by which a drug, fluid, poison, or other substance is taken into the body. For many pscbased therapies, the target site is usually at or near the site of cell loss or injury e. R outes of drug a dministration to laboratory a nimals common routes. Do not administer drugs via tubes that are being used for aspiration or are on free.
Before injecting, make sure that the tip of the needle is in the vein. Extrapolation of mdma findings from animals to humans requires assessment of pharmacokinetics in various species, and lowdose administration data from rats are lacking. Parenteral routes routes of administration other than enteral route are called parenteral routes. Start studying 8 routes of administration of drugs. The nursing profession has shown an increasing interest in this route of drug.
Implications for drug administration site of drug delivery most drugs absorbed in the jejunum drug absorption may be reduced due to ph alkaline environment or delivery beyond site of absorption function of enteral tube aspiration free drainage multilumen tubes. Sep 14, 2017 this video will help you to understand about basic pharmacology like what is drug what is pharmacokinetics what is pharmacodynamics routes of drug administration. The duration taken for drug action of subcutaneously administrated drug should be longer than the duration taken for drug action of other parenteral route of drug administration. Generally, an ebook can be downloaded in five minutes or less.
A route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body routes of administration are generally classified by the location at which the substance is applied. It is a method of delivering the drug directly into the blood stream without having to pass the oral or alimentary mucous layer. Parenteral mode of drug administration that avoids the git. Dec 21, 2016 routes of drug administration for mbbs 1st year dr. A route of administration in pharmacy is the path by which a drug is taken into the body. Pharmacokinetics of different routes of administration of. Rapid onset of action due to rapid access to circulation. Drugs are applied topically to the skin or mucous membranes, mainly for local action. Swallowed through the mouth into the stomach and digestive tract b. The drug is injected into the subcutaneous tissues of the thigh, abdomen and arm, e.
The rectal route of drug administration is a practical. The various routes of administrations are classified into following categories. Injectable preparations are usually sterile solutions or suspensions of drug in water. How to download notes in pdf from solution pharmacy facebook group using laptop using mobile.
This route is where a medicament is applied on to skin to produce its effects. What does conjunctival route of administration mean. Advantages of this topical route include direct, localized delivery to the target tissue, good accessibility into the intraocular environment owing to membrane permeability and large intercellular spaces, avoidance of hepatic firstpass. In this method of administration, drug is applied on to skin or other body surfaces.
Parenteral route of administration and dosage forms a drug given parenterally is one given by a route other than the mouth topical dosage forms are considered separately. Routes of drug administration advantages of inhalation rapid action of the drug, with local effects with in the respiratory tract potent drugs may be given in small amounts, minimizing the side effects convenience and comfort of the patient disadvantages of inhalation requires cooperation of the patient in proper breathing techniques for effectiveness adverse systemic side effects may result. Gastrointestinal oral per os through the mouth gavage into the stomach via a tube or gavage needle rectal per rectum into the rectum via the anus npo nil per os nothing by mouth. A route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body. However, the result obtained in our experiment show that the duration taken for drug action through subcutaneous route which is 28 minutes is shorter than the duration.
Purchase routes of drug administration 1st edition. Use of aseptic technique very very important intravenous iv injections fast action due to avoidance of gi absorption intradermal injected into the dermis. You are free to copy and communicate the work in its current form for noncommercial purposes, as long as you attribute the state of queensland, queensland ambulance service and comply with the licence terms. Routes can also be classified based on where the target of action is. Routes of drug administration to laboratory animals authorstream. Mar 10, 2020 drug administration routes science topic the various ways of administering a drug or other chemical to a site in a patient or animal from where the chemical is absorbed into the blood and. Nda 204200, original 2 adrenalin epinephrine injection, usp 1 mgml 6 reference id. This table is for illustrative purposes only and is subject to change. It also places the drinker at risk of accidents, arrests, poor job. Systemic route a enteral route b parenteral route 1.
Most of the drugs can be administered by variety of routes. Routes of administration pharmacology linkedin slideshare. Iv delivery permits a rapid effect and a maximal degree of control over the circulating levels of the drug. Different routes of administration, their advantages and disadvantages, suitable dosage forms to be delivered. Aerosols localtopical route of drug administration in this route the drug is applied on the skin. The rectal route has been used for administration of. Oral the most convenient and most commonly used route of administration examples are tablets, capsules, and liquids. Pharmacokinetics of rectal compared to intramuscular paracetamol. In this administration the drug is administered in the gaseous form. Drugs are usually injected into the muscle of the upper arm, thigh, or buttock. Common examples include oral and intravenous administration. Route of administration an overview sciencedirect topics. In this lesson, we defined that a parenteral drug administration is the delivery of a medication by injection into the body, and discussed the common types of injections to include.
Drug begins breaking down in the stomach and is absorbed into. The oral route of administration is the safest, most economical and the most convenient way of giving medicines. A scheme of the different sites for parenteral drug administration is presented in figure 6. Routes of drug administration pharmacology 3571 with. Download and create your own document with medication administration record 30kb 2 pages for free. Routes of administration of a drug are determined by its physical and chemical properties, patient characteristics and the rapidity of response desired. Administration of a drug to the conjunctiva, the most frequently used mode of ocular drug delivery. Obtain appropriate information before administering a drug by injection to ensure patient safety. Drug absorption the rate at which a drug reaches it site of action depends on. The production of this text has raised many questions concerning the data available relating to this method of medication administration. A method in which a drug is taken into the body listed from slowest to fastest. Working with accuracy objectives after completing this chapter, the student will be able to.
Route of administration should address three basic criteria. Preparing to administer a drug drugs local effect applied directly to skin, tissue, or mucous membranes systemic effect given by routes that allow the drug to be absorbed or distributed into the bloodstream pay close attention dose route form of medication. Techniques used for drug administration by pulmonary route two techniques can be used for administration of drugs by pulmonary route. Routes of drug administration to laboratory animals. A free powerpoint ppt presentation displayed as a flash slide show on id. Precautions drug should usually be injected slowly.
Introduction a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body. Drug administration routes science topic the various ways of administering a drug or other chemical to a site in a patient or animal from where the chemical is absorbed into the blood and. Absorption involves the passage of the drug from its site of administration into the blood distribution involves the delivery of the drug to the tissues 4. Pravin prasad 2nd year resident, md clinical pharmacology maharajgunj medical campus 18th december, 2016 3rd poush, 2073, sunday 2. A route of administration in pharmacology and toxicology is the path by which a drug, fluid. If you alter the work, you may not share or distribute the modified work. Routes of drug administration advantages of inhalation rapid action of the drug, with local effects with in the respiratory tract potent drugs may be given in small. In this study, we examine mdma pharmacokinetics in rats given low 2 mgkg and high 10. Oral route is the most common route of drug administration. This route of administration is possible if the drug is in liquid dosage form. Correlate the dosage forms with the appropriate route of administration. Routes of drug administration play a major role in a medical treatment. Confirm that the patient can take or receive the medication by the ordered route. Right route again, check the appropriateness of the route ordered.
We report here on the absorption and the systemic biological. Routes of drug administration 1 topical medication. Define the routes of administration for medications. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Download free medication administration record pdf. Routes of drug administration for mbbs 1st year dr. Routes of drug administration for bns 1st year slideshare. Drug administration drugs msd manual consumer version.
If necessary, calculate the dose and have another nurse calculate the dose as well. The pharmacokinetic parameters of four different routes of administration of a single dose of 400 microg of misoprostol were studied. A route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body classification routes of administration can broadly be divided into. The path taken by the drug to get into the body is known as the route of drug administration. Routes of administration inhalation route preferred route because onset is rapid smaller doses are needed compared to the oral route side effects e. For the subcutaneous route, a needle is inserted into fatty tissue just beneath the skin. This presentation describes various routes of drug administration. After a drug is injected, it then moves into small blood vessels capillaries and is carried away by the bloodstream. Routes of drug administration the route of administration roa that is chosen may have a profound effect upon the speed and. Alternatively, a drug reaches the bloodstream through the lymphatic vessels see figure. Because the muscles lie below the skin and fatty tissues, a longer needle is used. Intravenous route advantages iv is the most common parenteral route. Parenteral drug administration their types, advantages.
Administration of drugs by injection and other routes. Drug rehab centers facility may result in withdrawal tendencies and can lead to various mental as well as physical problems. That is the drug acts only at the site of application and. Routes of drug administration oral po oral administration will be covered in more detail in subsequent chapters. Dosage form design may also be used modify the rate of absorption. The choice of appropriate route largely depends both on the drug as well as patient related factors the route of administration is determined primarily by the properties of the drug for example, water or lipid solubility, ionization and by the therapeutic objectives for example, the desirability of a rapid onset of action,the. Absorption after oral administration can be quite variable.
Oral route the most common route of drug administration. This route is one of the safest route as the drug cannot product poisonous effects. Selecting a right route of drug administration by a physician improves patients health. Classification routes of administration can broadly be divided into. Describe the various dosage forms available for medications. This video will help you to understand about basic pharmacology like what is drug what is pharmacokinetics what is pharmacodynamics routes of drug. The intramuscular route is preferred to the subcutaneous route when larger volumes of a drug product are needed. It may be in the form of tablets, capsules, syrup, emulsions. High molecular weight drugs in general, and peptides in particular, are usually delivered by parenteral route because they are poorly absorbed or degraded in the gastrointestinal tract. Advantages safe convenient self administered, pain free, noninvasive and easy to take economical compared to other parentral routes usually good absorption takes place along the whole length of the gi tract no need for sterilization. Each route of administration has distinct advantages and disadvantages.
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